Luxury Panama Canal Cruises

Sail Central America from Atlantic to Pacific

View natural beauty and an engineering marvel across the Panama Canal

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Recommended Panama Canal Cruises

LuxuryOnly Panama Canal Cruises

Experience the trip of a lifetime as you navigate the 50-mile Panama Canal onboard a cheap Panama Canal cruise, including one of these highly-rated Panama Canal cruises:
  • Sirena
    4.1 rating out of 5  (78 reviews)

    10 Night Panama Potpourri

    Sirena

    Departing from: Miami, Florida
    Ports of Call:
    • Cozumel, Mexico
    • Costa Maya (Mahahual), Mexico
    • Santo Tomas De Castilla, Guatemala
    • Harvest Caye, Belize
    • Roatan (Isla Roatan), Bay Islands, Honduras
    • Puerto Limon, Costa Rica
    • Panama Canal Full Transit
    • Panama City, Panama
    Sailing Dates:
    • March 2025
    interior from
    $2,999
    $300pernight
    oceanview from
    $3,249
    $325pernight
    balcony from
    $4,699
    $470pernight
    suite from
    $6,299
    $630pernight
    All the Cruise Line Offers & More:
    • Up to $1,000 to Spend on Board
    • Up to $2,000 Visa Prepaid Card
    • Included Shore Excursions, Champagne, Gourmet Dining, more
    • Free Unlimited Wi-Fi
     
    Was $6,998 – Save up to 57%
    Interior from $2,999
    ($300pernight)
    4.1 rating out of 5  (78 reviews)
  • Insignia
    4.1 rating out of 5  (82 reviews)

    10 Night Palms & Panama Canal

    Insignia

    Departing from: Tampa, Florida
    Ports of Call:
    • Cozumel, Mexico
    • Costa Maya (Mahahual), Mexico
    • Belize City, Belize
    • Roatan (Isla Roatan), Bay Islands, Honduras
    • Puerto Limon, Costa Rica
    • Colon, Panama
    • Panama Canal Full Transit
    • Panama City (Fuerte Amador), Panama
    Sailing Dates:
    • March 2026
    interior from
    $2,999
    $300pernight
    oceanview from
    $3,299
    $330pernight
    balcony from
    $4,899
    $490pernight
    suite from
    $6,799
    $680pernight
    All the Cruise Line Offers & More:
    • Up to $1,000 to Spend on Board
    • Up to $2,000 Visa Prepaid Card
    • Exclusive: Gratuities for 2 Included
     
    Was $6,998 – Save up to 57%
    Interior from $2,999
    ($300pernight)
    4.1 rating out of 5  (82 reviews)
  • Insignia
    4.1 rating out of 5  (82 reviews)

    10 Night Canal & Coral Isles

    Insignia

    Departing from: Panama City (Fuerte Amador), Panama
    Ports of Call:
    • Panama Canal Full Transit
    • Cartagena, Colombia
    • Puerto Limon, Costa Rica
    • Roatan (Isla Roatan), Bay Islands, Honduras
    • Costa Maya (Mahahual), Mexico
    • Cozumel, Mexico
    • Miami, Florida
    Sailing Dates:
    • April 2026
    interior from
    $2,999
    $300pernight
    oceanview from
    $3,299
    $330pernight
    balcony from
    $4,899
    $490pernight
    suite from
    $6,799
    $680pernight
    All the Cruise Line Offers & More:
    • Up to $1,000 to Spend on Board
    • Up to $2,000 Visa Prepaid Card
    • Exclusive: Gratuities for 2 Included
     
    Was $6,998 – Save up to 57%
    Interior from $2,999
    ($300pernight)
    4.1 rating out of 5  (82 reviews)
  • Regatta
    4.1 rating out of 5  (126 reviews)

    12 Night Pacific Pathways

    Regatta

    Departing from: San Pedro (Los Angeles), California
    Ports of Call:
    • Ensenada, Mexico
    • Cabo San Lucas, Mexico
    • Acapulco, Mexico
    • Puerto Quetzal, Guatemala
    • Corinto, Nicaragua
    • Puntarenas, Costa Rica
    • Panama Canal Full Transit
    • Colon, Panama
    Sailing Dates:
    • November 2025
    interior from
    $3,599
    $300pernight
    oceanview from
    $3,949
    $329pernight
    balcony from
    $5,849
    $487pernight
    suite from
    $8,199
    $683pernight
    All the Cruise Line Offers & More:
    • Up to $1,000 to Spend on Board
    • Up to $2,000 Visa Prepaid Card
    • Included Shore Excursions, Champagne, Gourmet Dining, more
     
    Was $8,098 – Save up to 56%
    Interior from $3,599
    ($300pernight)
    4.1 rating out of 5  (126 reviews)
  • Nautica
    4.1 rating out of 5  (92 reviews)

    16 Night Beyond the Panama Canal

    Nautica

    Departing from: Miami, Florida
    Ports of Call:
    • Key West, Florida
    • Cartagena, Colombia
    • Panama Canal Full Transit
    • Puntarenas, Costa Rica
    • Corinto, Nicaragua
    • Puerto Quetzal, Guatemala
    • Acapulco, Mexico
    • Cabo San Lucas, Mexico
    • Ensenada, Mexico
    • San Pedro (Los Angeles), California
    Sailing Dates:
    • December 2024
    interior from
    $3,999
    $250pernight
    oceanview from
    $4,449
    $278pernight
    balcony from
    $6,499
    $406pernight
    suite from
    $9,999
    $625pernight
    All the Cruise Line Offers & More:
    • Up to $1,000 to Spend on Board
    • Up to $2,000 Visa Prepaid Card
    • Up to a 4-Category Upgrade
    • Included Shore Excursions, Champagne, Gourmet Dining, more
    • Free Unlimited Wi-Fi
     
    Was $8,598 – Save up to 53%
    Interior from $3,999
    ($250pernight)
    4.1 rating out of 5  (92 reviews)

Panama Canal Cruises ... Unbeatable Vacations For Less

Enjoy Huge Savings & Offers on Panama Canal Cruises

Take a break from ordinary vacations, and choose the adventure of a lifetime with a Panama Canal cruise. Offering fantastic voyages through both old and new ports with great shopping, culture and plenty of ways to wine and dine, there's never been a better way to escape the everyday. Most Panama Canal cruise vacations average around 14 nights, giving you and the rest of your party all the time in the world to soak up the sights and get away from it all.

Perhaps your Panama Canal cruise vacation will take you through the port of Huatulco, Mexico, where quaint villages meet upscale resorts - plus plenty of white-sand beaches to enjoy the waters of paradise. Enjoy a livelier environment in Cabo San Lucas, and dine at the world-renown Cabo Wabo Cantina Concert Hall & Restaurant, owned by rocker, Sammy Hagar. If you'd prefer to spend your time enjoying all the water sports that a Panama Canal cruise has to offer, don't miss the unbeatable scuba diving and snorkeling opportunities in Puntarenas, Costa Rica.

Regardless of which fantastic Panama Canal cruise itinerary you choose, you're sure to experience luxurious accommodations, fine dining options and daily entertainment aboard your cruise ship. Why settle for the hassle of multiple hotel stays and inconvenient transportation when you can have it all with a cruise vacation? Simply book your Panama Canal cruise getaway through www.CruiseOceania.com, and take advantage of the best prices and deals around.

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